Here is a list of the current Words With Friends power-ups and how to effectively use them:
This power-up allows you to swap out tiles without losing your turn. It can be extremely useful to gain major points. Having high-scoring letters gives you the opportunity to play high-scoring words. And using this will provide the chance of getting better letters without sacrificing a turn that could potentially lose you the game.
But before using this power-up, make sure to take a look at the Tile Bag and check if there are highly scored letters remaining and your chances of getting them. This way, you will be able to conserve your power-up and use it at the right time.
This power-up can also be helpful when trying to create a particular word where you do not have all of the letters. If you know that word will score big points and the letter you need is remaining in the bag it can be a smart move to make given the chances.
Hindsight is a little different from the rest of the power-ups as it does not immediately give you an advantage during your turn. This power-up lets you see the best possible move that could have been made from your previous play. This is mainly useful to see if you can still make that play or to use it as a learning tool.
This power-up allows you to see places where the most words can be played. It is helpful when you are having a hard time finding spaces for a high score.
But, using this will sometimes show too many spaces that it can still be challenging to find the right word. So it is smart to use this with the Strength meter so you know you are getting a high-scoring word worth the power-up.
This can especially be helpful during late-game when it is more difficult to find a spot to play words. It will be beneficial when you are running out of tiles so that it is easier to find the word it is hinting.
This power-up is somewhat like Word Radar in that it helps you find where to put a word. However, Word Clue highlights one place on the board along with which tiles to use.
But, it will not always show you the highest scoring available word. It can be useful when you have no idea where to play another word so you can get some type of score.
This should only be used when you do not have any blank tiles.
Word Clue would be able to provide a word using a blank tile making it extremely difficult to make up the word it is hinting when having to guess the right letter.